University College London - Queen Square
Principal investigator:
Prof. Henry Houlden
University College London
Institute of Neurology
Queen Square
WC1N 3 BG London UK
Expertise of the participating organisation:
The Institute of Neurology and the National Hospital for Neurology and Neurosurgery, Queen Square, is the foremost specialist clinical and research centre in neurology in the United Kingdom. It has a unique concentration of academic consultants with a clinical and research interest in MSA. Professor Quinn is a retired Neurologist who has published widely on MSA, particularly in collaboration with Professor Wenning in Innsbruck), and also with Professor Tison in Bordeaux and with Professor Brooks in London . He developed the most widely used clinical diagnostic criteria for MSA. Professor Mathias, Professor of Neurovascular Medicine, directs the Autonomic Unit (Queen Square) and Neurovascular Medicine Unit (St Mary's Hospital) these are national centres, with many European referrals, for various autonomic disorders, especially MSA. The Units have pioneered new methods of diagnosis and been principal investigators in therapeutic trials in MSA.
Professor Fowler, Professor in Uro-neurology, is the first and only uro-neurologist in the UK, and the leading authority on uro-neurological and genital dysfunction in parkinsonism and MSA. All of the above have a special clinical and research interest in MSA, they all have a substantial MSA patient base, and have all published extensively, often together, on MSA.
Recent publications relevant to the EMSA-SG:
Schottlaender LV, Bettencourt C, Kiely AP, Chalasani A, Neergheen V, Holton JL, Hargreaves I, Houlden H. Coenzyme Q10 Levels Are Decreased in the Cerebellum of Multiple-System Atrophy Patients. PLoS One 2016;11:e0149557.
Sailer A, Scholz SW, Nalls MA, Schulte C, Federoff M, Price TR, Lees A, Ross OA, Dickson DW, Mok K, Mencacci NE, Schottlaender L, Chelban V, Ling H, O'Sullivan SS, Wood NW, Traynor BJ, Ferrucci L, Federoff HJ, Mhyre TR, Morris HR, Deuschl G, Quinn N, Widner H, Albanese A, Infante J, Bhatia KP, Poewe W, Oertel W, Hoglinger GU, Wullner U, Goldwurm S, Pellecchia MT, Ferreira J, Tolosa E, Bloem BR, Rascol O, Meissner WG, Hardy JA, Revesz T, Holton JL, Gasser T, Wenning GK, Singleton AB, Houlden H, European Multiple System Atrophy Study G, the UKMSASG. A genome-wide association study in multiple system atrophy. Neurology 2016.
Federoff M, Price TR, Sailer A, Scholz S, Hernandez D, Nicolas A, Singleton AB, Nalls M, Houlden H. Genome-wide estimate of the heritability of Multiple System Atrophy. Parkinsonism Relat Disord 2016;22:35-41.
Federoff M, Schottlaender LV, Houlden H, Singleton A. Multiple system atrophy: the application of genetics in understanding etiology. Clin Auton Res 2015;25:19-36.
Schottlaender LV, Houlden H, Multiple-System Atrophy Brain Bank C. Mutant COQ2 in multiple-system atrophy. N Engl J Med 2014;371:81.
Schottlaender LV, Holton JL, Houlden H. Multiple system atrophy and repeat expansions in C9orf72. JAMA Neurol 2014;71:1190-1191.
Segarane B, Li A, Paudel R, Scholz S, Neumann J, Lees A, Revesz T, Hardy J, Mathias CJ, Wood NW, Holton J, Houlden H. Glucocerebrosidase mutations in 108 neuropathologically confirmed cases of multiple system atrophy. Neurology 2009;72:1185-1186.
Quinn N, Barker RA, Wenning GK. Are trials of intravascular infusions of autologous mesenchymal stem cells in patients with multiple system atrophy currently justified, and are they effective? Clin Pharmacol Ther 2008; 83: 663-5.
Schrag A, Wenning GK, Quinn N, Ben-Shlomo Y. Survival in multiple system atrophy. Mov Disord 2008; 23: 294-6.
Schrag A, Selai C, Mathias C, Low P, Hobart J, Brady N, et al. Measuring health-related quality of life in MSA: the MSA-QoL. Mov Disord 2007; 22: 2332-8.
Mathias CJ. Multiple system atrophy and autonomic failure. J Neural Transm Suppl 2006: 343-7.
Paviour DC, Williams D, Fowler CJ, Quinn NP, Lees AJ. Is sphincter electromyography a helpful investigation in the diagnosis of multiple system atrophy? A retrospective study with pathological diagnosis. Mov Disord 2005; 20: 1425-30.
Quinn NP. How to diagnose multiple system atrophy. Mov Disord 2005; 20 Suppl 12: S5-S10.
The Imperial College of Sciences Technology and Medicine - MRC Cyclotron Unit
Principal investigator:
Prof. David J. Brooks
The Imperial College of Sciences
Technology and Medicine
MRC Cyclotron Unit
150 DuCane Road
W12 0NN London UK
david.brooks(at)csc.mrc.ac.uk
Expertise of the participating organization:
Professor Brooks and his team at the MRC Cyclotron Unit have been performing PET studies in-patients with typical and atypical parkinsonian syndromes since 1986. They have a variety of metabolic and ligand tracers available including markers of dopaminergic, opioid, GABA, adenosine, substance P, and microglial function.
Recent publications relevant to the EMSA-SG:
Lewis SJ, Pavese N, Rivero-Bosch M, Eggert K, Oertel W, Mathias CJ, Brooks DJ, Gerhard A. Brain monoamine systems in multiple system atrophy: a positron emission tomography study. Neurobiol Dis 2012;46:130-136.
Brooks DJ. Can imaging separate multiple system atrophy from Parkinson's disease? Mov Disord 2012;27:3-5.
Brooks DJ, Seppi K, Neuroimaging Working Group on MSA. Proposed neuroimaging criteria for the diagnosis of multiple system atrophy. Mov Disord 2009;24:949-964.
Berding G, Brucke T, Odin P, Brooks DJ, Kolbe H, Gielow P, et al. [[123I]beta-CIT SPECT imaging of dopamine and serotonin transporters in Parkinson's disease and multiple system atrophy. Nuklearmedizin 2003; 42: 31-8.
Gerhard A, Banati RB, Goerres GB, Cagnin A, Myers R, Gunn RN, et al. [11C](R)-PK11195 PET imaging of microglial activation in multiple system atrophy. Neurology 2003; 61: 686-9.
Hu MT, Chaudhuri KR, Jarosz J, Yaguez L, Brooks DJ. An imaging study of parkinsonism among African-Caribbean and Indian London communities. Mov Disord 2002; 17: 1321-8.
Chaudhuri KR, Hu MT, Brooks DJ. Atypical parkinsonism in Afro-Caribbean and Indian origin immigrants to the UK. Mov Disord 2000; 15: 18-23.
Reuter I, Hu MT, Andrews TC, Brooks DJ, Clough C, Chaudhuri KR. Late onset levodopa responsive Huntington's disease with minimal chorea masquerading as Parkinson plus syndrome. J Neurol Neurosurg Psychiatry 2000; 68: 238-41.
University of College London - PDS Brain Research Centre
Principal investigator:
Prof. Andrew Lees
University of College London
PDS Brain Research Centre
Institute of Neurology
1 Wakefield Street
WC1N 1 PJ London UK
a.lees(at)ion.ucl.ac.uk
Expertise of the participating organization:
The PDS-BRC (Parkinson's Disease Society Brain Bank Research Centre) is the largest dedicated brain tissue resource for Parkinson syndromes in the world with a collection of more than 800 Parkinsonian brains. Over the last ten years it has been responsible for " feeding research" in house and in other laboratories nationally and internationally leading to improved understanding of the pathogenesis of parkinson syndromes including MSA.
Recent publications relevant to the EMSA-SG:
Ling H, Asi YT, Petrovic IN, Ahmed Z, Prashanth LK, Hazrati LN, Nishizawa M, Ozawa T, Lang A, Lees AJ, Revesz T, Holton JL. Minimal change multiple system atrophy: an aggressive variant? Mov Disord 2015;30:960-967.
Asi YT, Ling H, Ahmed Z, Lees AJ, Revesz T, Holton JL. Neuropathological features of multiple system atrophy with cognitive impairment. Mov Disord 2014;29:884-888.
Ling H, Petrovic IN, Lang AE, Lees AJ. Reply to letter: Multiple system atrophy-parkinsonism with slow progression and prolonged survival: a diagnostic catch. Mov Disord 2013;28:408.
Kiely AP, Asi YT, Kara E, Limousin P, Ling H, Lewis P, Proukakis C, Quinn N, Lees AJ, Hardy J, Revesz T, Houlden H, Holton JL. alpha-Synucleinopathy associated with G51D SNCA mutation: a link between Parkinson's disease and multiple system atrophy? Acta Neuropathol 2013;125:753-769.
Ahmed Z, Asi YT, Lees AJ, Revesz T, Holton JL. Identification and quantification of oligodendrocyte precursor cells in multiple system atrophy, progressive supranuclear palsy and Parkinson's disease. Brain Pathol 2013;23:263-273.
Petrovic IN, Ling H, Asi Y, Ahmed Z, Kukkle PL, Hazrati LN, Lang AE, Revesz T, Holton JL, Lees AJ. Multiple system atrophy-parkinsonism with slow progression and prolonged survival: a diagnostic catch. Mov Disord 2012;27:1186-1190.
Massey LA, Micallef C, Paviour DC, O'Sullivan SS, Ling H, Williams DR, Kallis C, Holton JL, Revesz T, Burn DJ, Yousry T, Lees AJ, Fox NC, Jager HR. Conventional magnetic resonance imaging in confirmed progressive supranuclear palsy and multiple system atrophy. Mov Disord 2012;27:1754-1762.
Glass PG, Lees AJ, Mathias C, Mason L, Best C, Williams DR, Katzenschlager R, Silveira-Moriyama L. Olfaction in pathologically proven patients with multiple system atrophy. Mov Disord 2012;27:327-328.
Ahmed Z, Asi YT, Sailer A, Lees AJ, Houlden H, Revesz T, Holton JL. The neuropathology, pathophysiology and genetics of multiple system atrophy. Neuropathol Appl Neurobiol 2012;38:4-24.
Silveira-Moriyama L, Gonzalez AM, O'Sullivan SS, Williams DR, Massey L, Parkkinen L, Ahmed Z, de Silva R, Chacon JR, Revesz T, Lees AJ, Holton JL. Concomitant progressive supranuclear palsy and multiple system atrophy: more than a simple twist of fate? Neurosci Lett 2009;467:208-211.
O'Sullivan SS, Massey LA, Williams DR, Revesz T, Lees A, Holton J. Parkinson's disease with Onuf's nucleus involvement mimicking multiple system atrophy. BMJ Case Rep 2009;2009.
O'Sullivan SS, Holton JL, Massey LA, Williams DR, Revesz T, Lees AJ. Parkinson's disease with Onuf's nucleus involvement mimicking multiple system atrophy. J Neurol Neurosurg Psychiatry 2008; 79: 232-4.
O'Sullivan SS, Massey LA, Williams DR, Silveira-Moriyama L, Kempster PA, Holton JL, et al. Clinical outcomes of progressive supranuclear palsy and multiple system atrophy. Brain 2008; 131: 1362-72.
Williams DR, Lees AJ. How do patients with parkinsonism present? A clinicopathological study. Intern Med J 2008.
Williams DR, Warren JD, Lees AJ. Using the presence of visual hallucinations to differentiate Parkinson's disease from atypical Parkinsonism. J Neurol Neurosurg Psychiatry 2007.
Williams DR, Watt HC, Lees AJ. Predictors of falls and fractures in bradykinetic rigid syndromes: a retrospective study. J Neurol Neurosurg Psychiatry 2006; 77: 468-73.
Pirtosek Z, Jahanshahi M, Barrett G, Lees AJ. Attention and cognition in bradykinetic-rigid syndromes: an event-related potential study. Ann Neurol 2001; 50: 567-73.