Petach-Tiqva

Principal investigator:

Dr. Ruth Djaldetti

Department of Neurology,
Rabin Medical Center,
Beilinson Campus,
49100 Petach-Tiqva,
Israel
yhaimi(at)bezegint.net

Expertise of the participating organization:

The Movement Disorder Clinic of Rabin Medical Center, Petah Tiqva, Israel, is a tertiary-care facility that treats mainly patients with parkinsonian disorders. The head of the clinic is Dr. Ruth Djaldetti, a senior staff member in the Department of Neurology. Dr. Djaldetti has conducted many clinical and research studies in patients with Parkinson?s disease and MSA. She also gained important experience in basic research on animal models of Parkinson?s disease as a research fellow at Columbia University in New York. The Department of Neurology is headed by Professor Eldad Melamed, a movement disorder specialist. Professor Melamed is also the director of the National Parkinson Foundation (U.S.A), Center of Research Excellence, and of the Laboratory of Neuroscience, Felsenstein Research Center.
The main interest of the laboratory is exploration of the mechanisms responsible for neurodegenerative diseases. Much effort is currently being invested in stem cell transplantation into the striatum in animal models of Parkinson?s disease and plans are underway to expand this approach to models of MSA.

Recent publications relevant to the EMSA-SG:

Yust-Katz S, Tesler D, Treves TA, Melamed E, Djaldetti R. Handedness as a predictor of side of onset of Parkinson's disease. Parkinsonism Relat Disord 2008. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18346926

Djaldetti R, Treves TA, Ziv I, Melamed E, Lorberboym M. 123I-FP-CIT SPECT imaging of dopamine transporters in patients with recurrent sudden falls: are such falls a distinct entity? J Nucl Med Technol 2007; 35: 232-6. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18006592

Djaldetti R, Yust-Katz S, Kolianov V, Melamed E, Dabby R. The effect of duloxetine on primary pain symptoms in Parkinson disease. Clin Neuropharmacol 2007; 30: 201-5. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17762316

Melamed E, Ziv I, Djaldetti R. Management of motor complications in advanced Parkinson's disease. Mov Disord 2007; 22 Suppl 17: S379-84. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18175400

Dabby R, Djaldetti R, Shahmurov M, Treves TA, Gabai B, Melamed E, et al. Skin biopsy for assessment of autonomic denervation in Parkinson's disease. J Neural Transm 2006; 113: 1169-76. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16835698

Djaldetti R, Ziv I, Melamed E. The mystery of motor asymmetry in Parkinson's disease. Lancet Neurol 2006; 5: 796-802. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16914408

Djaldetti R, Hellmann M, Melamed E. Bent knees and tiptoeing: late manifestations of end-stage Parkinson's disease. Mov Disord 2004; 19: 1325-8. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=15389997

Djaldetti R, Giladi N, Hassin-Baer S, Shabtai H, Melamed E. Pharmacokinetics of etilevodopa compared to levodopa in patients with Parkinson's disease: an open-label, randomized, crossover study. Clin Neuropharmacol 2003; 26: 322-6. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=14646613